How to love the world of Cyp-40

How to love the world of Cyp-40

Photo by Trust "Tru" Katsande on Unsplash

Originally published 30 December 1996

There is only one ques­tion, says the poet Mary Oliv­er: “How to love this world.”

I thought of that the oth­er day while I was scan­ning the jour­nal Sci­ence, the week­ly jour­nal of the Amer­i­can Asso­ci­a­tion for the Advance­ment of Sci­ence. It is this coun­try’s pre­mier mul­ti­dis­ci­pli­nary jour­nal for bring­ing cut­ting-edge research to a broad sci­en­tif­ic audience.

Many arti­cles are beyond my com­pre­hen­sion; for exam­ple, “Mol­e­c­u­lar Chap­er­one Machines: Chap­er­one Activ­i­ties of the Cyclophilin Cyp-40 and the Steroid Apore­cep­tor-Asso­ci­at­ed Pro­tein p23.”

Nev­er­the­less, I can get a gen­er­al idea of what’s going on across the sci­en­tif­ic dis­ci­plines, and com­men­taries in the jour­nal trans­late some of the more inter­est­ing arti­cles into ordi­nary English.

As I was read­ing, I asked myself: Does this sci­en­tif­ic infor­ma­tion help me love the world?

In her poet­ry, Oliv­er bril­liant­ly evokes the sen­sate stim­uli of love: the “lapped light” of pond lilies in the black pond, the goldfinch hatch­lings “in the sway­ing branch­es, in the sil­ver bas­kets,” the dead snake in the road “as cool and gleam­ing as a braid­ed whip.”

Who can walk in the world that Oliv­er describes and not be blown over by love, made stam­mer­ing and speechless?

And here I am wad­ing through arti­cles with titles like “Sur­vival of Cholin­er­gic Fore­brain Neu­rons in Devel­op­ing p75NGFR-Defi­cient Mice.” What is here, among this tech­ni­cal lan­guage, to pluck the heartstrings?

I’ll tell you.

Here is an arti­cle about a screen­ing of more than a mil­lion zebrafish embryos for devel­op­men­tal defects by two teams of sci­en­tists at the Max Planck Insti­tute of Devel­op­men­tal Biol­o­gy in Ger­many and Boston’s Mass­a­chu­setts Gen­er­al Hos­pi­tal. This is the first time that such a com­pre­hen­sive study has been done for a ver­te­brate species.

Embryo­ge­n­e­sis, the trans­for­ma­tion of a sin­gle fer­til­ized egg into a ful­ly devel­oped zebrafish — or fruit fly, or human being — is one of the most pro­found mys­ter­ies con­fronting the human mind. By iso­lat­ing the dam­aged genes that caused the zebrafish muta­tions, the researchers hope even­tu­al­ly to recon­struct the huge­ly com­plex path­ways of gene tran­scrip­tion and pro­tein action that guide embryogenesis.

Here too is an arti­cle about neu­ro­sci­en­tists at Wash­ing­ton Uni­ver­si­ty in St. Louis who used positron emis­sion tomog­ra­phy (PET scans) to obtain images of brain activ­i­ty as human sub­jects learned to trace a maze with a pen.

As the sub­jects pro­ceed­ed in their task by tri­al and error, learn­ing to solve a prob­lem, draw­ing upon dif­fer­ent strate­gies and skills, the researchers watched in real time, on the screen of a com­put­er, as activ­i­ty flick­ered in dif­fer­ent parts of the brain. Here are images of the music of thought — ada­gios, alle­gros, and crescen­dos of danc­ing col­or — as the mind goes about its busi­ness of mak­ing sense of the world.

Here are a series of arti­cles on recent progress in under­stand­ing the cell cycle. At every moment of our lives, the tril­lions of cells in our bod­ies are spin­ning out copies of them­selves. This requires an aston­ish­ing­ly accu­rate repli­ca­tion of chro­mo­somes, chem­i­cal syn­the­sis, timing.

Our bod­ies are like wheat fields of mol­e­cules blown through by a nev­er-ceas­ing wind called life. We are obliv­i­ous to the con­stant and remark­able mir­a­cles of cel­lu­lar repli­ca­tion that main­tain our phys­i­cal integri­ty. Mol­e­c­u­lar biol­o­gists are teas­ing out the chem­istry that makes it possible.

Here is an arti­cle on nitro­gen that has entered the envi­ron­ment through the use of agri­cul­tur­al chem­i­cals and the burn­ing of fos­sil fuels. It used to be thought that this excess nitro­gen would encour­age the growth of plants that sop up car­bon diox­ide from the atmos­phere, there­by slow­ing the buildup of this green­house gas and post­pon­ing glob­al warm­ing — a good thing.

But now a study by ecol­o­gists at the Uni­ver­si­ty of Toron­to and the Uni­ver­si­ty of Min­neso­ta shows that while in the short term nitro­gen does spur growth, in the long term it leads to a replace­ment of native plants by fast-grow­ing, inva­sive species that are inef­fi­cient at fix­ing car­bon in soils, there­by con­tribut­ing to glob­al warming.

We dis­cov­er what a fine­ly tuned engine is the ecosys­tem of the Earth, through which we clum­si­ly walk at our peril.

All of this is just a frac­tion of the knowl­edge to be gleaned from a sin­gle issue of one sci­en­tif­ic jour­nal. What we glimpse in these reports is the invis­i­ble machin­ery of the word, the vast mag­ic of life, the green fuse that burns in every liv­ing thing — ignit­ing, cre­at­ing, animating.

We glimpse what the poet Mary Oliv­er calls “the light at the cen­ter of every cell,” and again, “the white fire of a great mystery.”

Yes, there is only one ques­tion: How to love this world? That’s why I read poets. That’s also why I read sci­ence. When it’s over, I want to say with Oliver:

all my life
I was a bride married to amazement.
I was the bridegroom, taking the world into my arms.
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